Disadvantages of APE

Cosmopolitan, it can build an APE(Actually Portable Executable) that runs in Windows, Linux, and macOS directly. By some hacky way like using MZ magic bytes and running shell script to redirect execution in Unix platforms.

Many people show me this project's advantages, but no one shows its disadvantages. Here's what I found:

In a word, APE is fantastic, however, it has many disadvantages and will not be the popular way to ship binaries to users. Use by your case, please.